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Abstract Macrotextured silicone breast implants are associated with several complications, ranging from seromas and hematomas to the formation of a rare type of lymphoma, known as breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). The presence of silicone wear debris has been detected within the peri-implant region and fibrotic capsule and histological analyses reveal inflammatory cells surrounding debris particles. However, it is unclear how these debris particles are generated and released from macrotextured implant surfaces, and whether wear debris generation is related to implant stiffness. In this study, we created an accelerated implant aging model to investigate the formation of silicone wear debris produced from self-mated (“shell-shell”) tribological interactions. We created implant-like silicone elastomers from polydimethylsiloxane (PDMS) using Sylgard 184 base:curing agent (10:1, 12:1, and 16:1) and quantified their mechanical properties (E* = 1141 ± 472, 336 ± 20, and 167 ± 53 kPa, respectively). We created macrotextured PDMS samples using the lost-salt technique and compared their self-mated friction coefficient (< µ > = 4.8 ± 3.2, 4.9 ± 1.8, and 6.0 ± 2.3, respectively) and frictional shear stress (τ = 3.1 ± 1.3, 3.2 ± 1.7, and 2.4 ± 1.4 MPa, respectively) to those of the recalled Allergan Biocell macrotextured implant shell (E* = 299 ± 8 kPa, < µ > = 2.2, andτ = 0.8 ± 0.1). Friction coefficient and frictional shear stress were largely insensitive to variations in elastic modulus for macrotextured PDMS samples and recalled implant shells. The stiffest 10:1 PDMS macrotextured sample and the recalled implant shell both generated similar area fractions of silicone wear debris. However, the recalled implant shell released far more particles (> 10×), mainly within the range of 5 to 20 µm²in area. Bone marrow-derived macrophages (BMDMs) were treated with several concentrations of tribologically generated silicone wear debris. We observed widespread phagocytosis of wear debris particles and increasing secretion of inflammatory cytokines with increasing concentration of wear debris particles. Our investigation highlights the importance of avoiding macrotextured surfaces and mitigating wear debris generation from silicone implants to reduce chronic inflammation.